GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs34226052 | 1 | rs62309960 | chr4:89152616 | ABCG2 | chr4:89011417-89152474:- | -0.22 | -3.6 | 0.000354 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs34226052 | 1 | rs62309962 | chr4:89152990 | ABCG2 | chr4:89011417-89152474:- | -0.19 | -3.38 | 0.000786 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs1061377 | 1 | rs62310332 | chr4:39114559 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.73 | 1.77E-8 | Uric acid levels |
| THCA | cis | rs11097912 | 1 | rs62321365 | chr4:107013723 | TBCK | chr4:106967233-107237861:- | 0.35 | 7.21 | 2.22E-12 | Airflow obstruction |
| THCA | cis | rs1109501 | 1 | rs62322549 | chr4:71319058 | AMTN | chr4:71384298-71398459:+ | 0.22 | 5.31 | 1.68E-7 | Alcoholism (heaviness of drinking) |
| THCA | cis | rs11734488 | 1 | rs62324382 | chr4:139125762 | SLC7A11 | chr4:139085248-139163503:- | 0.23 | 4.6 | 5.34E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs7664683 | 1 | rs62329461 | chr4:103261217 | BANK1 | chr4:102341118-102995967:+ | -0.24 | -3.4 | 0.000729 | Erythrocyte cadmium concentration in never smokers |
| THCA | cis | rs7664683 | 1 | rs62329462 | chr4:103264105 | BANK1 | chr4:102341118-102995967:+ | -0.25 | -3.61 | 0.000342 | Erythrocyte cadmium concentration in never smokers |
| THCA | cis | rs1466662 | 1 | rs62331930 | chr4:155349319 | DCHS2 | chr4:155155527-155412930:- | 0.16 | 3.49 | 0.000526 | Alzheimer's disease (age of onset) |
| THCA | cis | rs7713317 | 1 | rs6234 | chr5:95728974 | RIOK2 | chr5:96496572-96519005:- | 0.17 | 3.63 | 0.000313 | Body mass index |
| THCA | cis | rs7713317 | 1 | rs6235 | chr5:95728898 | RIOK2 | chr5:96496572-96519005:- | 0.18 | 3.66 | 0.000281 | Body mass index |
| THCA | cis | rs10043228 | 1 | rs62384189 | chr5:115510391 | COMMD10 | chr5:115420727-115628978:+ | 0.47 | 5.68 | 2.31E-8 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs10043228 | 1 | rs62384212 | chr5:115521667 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.84 | 9.44E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs10043228 | 1 | rs62384213 | chr5:115526795 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.7 | 2.09E-8 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs10043228 | 1 | rs62384215 | chr5:115528198 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.7 | 2.09E-8 | Asthma or chronic obstructive pulmonary disease |